' 
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
USERS' SCORE
Good
Based on 39 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
9
Selenium aids Graves' orbitopathy treatment
The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
Directly addresses selenium's effects
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
Read More
0
Selenium supplementation ineffective for AITD
A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease.
Directly assesses selenium's effect
We aimed to explore how selenium affects autoimmune thyroid disease (AITD), specifically looking at three conditions: autoimmune thyroiditis (AIT), autoimmune hyperthyroidism (AIH), and Graves' disease (GD). Using a research method called Mendelian randomization, we analyzed genetic data to establish potential causal links between selenium levels and these autoimmune disorders.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
Read More
9
Selenium reduces thyroid autoantibodies
Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.
High relevance to autoimmune research
We explored the effects of selenium supplements on patients with Hashimoto's thyroiditis, an autoimmune disorder that can affect thyroid function. Through a structured analysis of studies, we focused on how selenium could potentially lower the levels of thyroid autoantibodies.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Read More
Most Useful Reviews
9.5
Improved skin health
Great supplement! I’m currently on my second jar, as advised by a nutritionist based on test results. After a short time, she observed that my skin became incredibly smooth, with cracks and dryness disappearing. My chronic runny nose and congestion have also resolved, leading to an overall improvement in my condition. Selenium is advised to take in courses for those with thyroid issues. I will order more!
Read More
0
Negative side effects
I started taking this following my doctor's advice for autoimmune thyroiditis. Initially, it seemed fine, but after four days, I experienced swelling and weakness. I did not immediately link these symptoms to the supplement. After stopping it, my health did not return to normal until two or three days later. I cannot recommend this product!
Read More
9.5
Lowered antibodies
With my autoimmune thyroid disease, I discovered that selenium is vital for our body's functioning. After my first bottle, my antibody levels dropped to normal, surprising my doctor. The inclusion of vitamin E as an antioxidant is excellent. This is a working supplement I wholeheartedly recommend!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
- All Researches
9
Selenium reduces thyroid autoantibodies
Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.
High relevance to autoimmune research
We explored the effects of selenium supplements on patients with Hashimoto's thyroiditis, an autoimmune disorder that can affect thyroid function. Through a structured analysis of studies, we focused on how selenium could potentially lower the levels of thyroid autoantibodies.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Read More
9
Selenium aids Graves' orbitopathy treatment
The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
Directly addresses selenium's effects
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
Read More
9
Selenium benefits autoimmune thyroiditis
Reassessing Selenium for the Management of Hashimoto's Thyroiditis: The Selini Shines Bright for Autoimmune Thyroiditis Patients.
High relevance to the study
The study we looked into focused on selenium's impact on autoimmune thyroiditis, particularly Hashimoto's thyroiditis. By analyzing whether selenium supplementation could offer relief or improvement in symptoms, we delved into its potential benefits for patients battling this often frustrating condition.
Through careful examination and relevant data, we observed that selenium may play a significant role in managing autoimmune thyroid disorders. Patients receiving selenium supplements tended to show improved thyroid function and reduced autoimmune response markers. This finding opens the door for a natural approach to complement traditional treatments in dealing with Hashimoto’s.
Overall, we found evidence supporting the use of selenium as a valuable addition to the treatment regimen for patients with autoimmune thyroiditis. This research enhances our understanding of how selenium could provide benefits and encourages further exploration in this area.
Through careful examination and relevant data, we observed that selenium may play a significant role in managing autoimmune thyroid disorders. Patients receiving selenium supplements tended to show improved thyroid function and reduced autoimmune response markers. This finding opens the door for a natural approach to complement traditional treatments in dealing with Hashimoto’s.
Overall, we found evidence supporting the use of selenium as a valuable addition to the treatment regimen for patients with autoimmune thyroiditis. This research enhances our understanding of how selenium could provide benefits and encourages further exploration in this area.
Read More
8
Selenium's impact on autoimmune thyroiditis
Selenium nutritional status and thyroid dysfunction.
Supports selenium in autoimmune treatment
We observed that selenium, an essential micronutrient, significantly impacts thyroid health, especially in the context of autoimmune disorders. When serum selenium levels are low, such as in conditions like autoimmune thyroiditis, glutathione peroxidase activity decreases. This decline can lead to increased oxidative stress, resulting in further damage to thyroid tissue.
Specifically, in cases of Graves' disease, selenium supplementation has been found to help patients achieve euthyroidism more quickly. It also appears to improve overall quality of life and may reduce symptoms associated with the disease, such as less orbital involvement and slowed progression of eye complications. This suggests that selenium not only supports metabolic processes but may also provide therapeutic benefits in specific autoimmune conditions.
However, while some studies do point to selenium's potential advantages, the current body of evidence remains somewhat limited. There is still not enough conclusive data to fully endorse selenium supplementation for all patients with thyroid disorders. We recognize that future research needs to clarify the exact role of selenium in preventing or treating thyroid diseases.
Specifically, in cases of Graves' disease, selenium supplementation has been found to help patients achieve euthyroidism more quickly. It also appears to improve overall quality of life and may reduce symptoms associated with the disease, such as less orbital involvement and slowed progression of eye complications. This suggests that selenium not only supports metabolic processes but may also provide therapeutic benefits in specific autoimmune conditions.
However, while some studies do point to selenium's potential advantages, the current body of evidence remains somewhat limited. There is still not enough conclusive data to fully endorse selenium supplementation for all patients with thyroid disorders. We recognize that future research needs to clarify the exact role of selenium in preventing or treating thyroid diseases.
Read More
8
Selenium improves gut immune health
Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus.
Study links selenium and autoimmune response
We explored the effects of selenium treatment on immune dysregulation in lupus, a common autoimmune disorder. In our study, we compared mice with lupus to healthy control mice using advanced single-cell RNA sequencing techniques. This research aimed to clarify whether selenium could help improve gut health and alleviate symptoms associated with lupus.
Our findings revealed a significant decrease in specific immune cells known as CD8αα + intraepithelial lymphocytes (IELs) in the lupus mice. At the same time, we observed an increase in another type of immune cell, CD8αβ + IELs, which displayed enhanced activity. Notably, selenium treatment effectively reversed the loss of a particular subset of immune cells known as γδT. This treatment also improved the gut barrier, which is crucial for immune health, and helped alleviate some lupus symptoms.
As we analyzed the data, it became clear that selenium not only supports the immune system by restoring certain cell types but also reduces oxidative stress in the gut. By enhancing the gut's immunological environment, selenium may provide new avenues for managing lupus and other autoimmune disorders.
Our findings revealed a significant decrease in specific immune cells known as CD8αα + intraepithelial lymphocytes (IELs) in the lupus mice. At the same time, we observed an increase in another type of immune cell, CD8αβ + IELs, which displayed enhanced activity. Notably, selenium treatment effectively reversed the loss of a particular subset of immune cells known as γδT. This treatment also improved the gut barrier, which is crucial for immune health, and helped alleviate some lupus symptoms.
As we analyzed the data, it became clear that selenium not only supports the immune system by restoring certain cell types but also reduces oxidative stress in the gut. By enhancing the gut's immunological environment, selenium may provide new avenues for managing lupus and other autoimmune disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 39 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved skin health
Great supplement! I’m currently on my second jar, as advised by a nutritionist based on test results. After a short time, she observed that my skin became incredibly smooth, with cracks and dryness disappearing. My chronic runny nose and congestion have also resolved, leading to an overall improvement in my condition. Selenium is advised to take in courses for those with thyroid issues. I will order more!
Read More
0
Negative side effects
I started taking this following my doctor's advice for autoimmune thyroiditis. Initially, it seemed fine, but after four days, I experienced swelling and weakness. I did not immediately link these symptoms to the supplement. After stopping it, my health did not return to normal until two or three days later. I cannot recommend this product!
Read More
9.5
Lowered antibodies
With my autoimmune thyroid disease, I discovered that selenium is vital for our body's functioning. After my first bottle, my antibody levels dropped to normal, surprising my doctor. The inclusion of vitamin E as an antioxidant is excellent. This is a working supplement I wholeheartedly recommend!
Read More
9.5
Supports thyroid health
My favourite selenium! Prescribed by a neurologist, this supplement helps my three-year-old fight oxidation and supports their thyroid gland. I’ve ordered more and now take it with my husband too. I appreciate its added vitamin E for better absorption. Quality is excellent.
9.5
Improved thyroid function
Prescribed for hyperthyroid function, I find it beneficial for everyone regardless of thyroid issues. A friend not only stopped her hair loss while taking it, but I also noticed my face and back rashes disappeared. My energy improved, and my thyroid function is better. The doctor is pleased with this complex, and I plan to continue taking it intermittently.
Read More
